TUM has moved up almost 40 places in the QS World University Rankings within just 10 years. In Germany, it is number one for the 11th consecutive year. “Being ranked among the best 25 universities is a brilliant affirmation for the hard work of our university community,” says TUM President Prof. Thomas F. Hofmann. “By forging closer ties between disciplines in research and teaching than other universities, we realize the enormous potential of our range of subjects – unmatched in Europe – extending from engineering and natural sciences to medicine, economics and social sciences. We are a vital hub for the exchange between industry, policy makers and civil society actors where they can identify key issues and collaborate on solutions. With our partners, including world-leading tech companies, and with our TUM Venture Labs as springboards for start-ups, we have turned Munich into one of the most dynamic innovation ecosystems. Furthermore, we are recruiting the best minds from all over the world. The diversity of the talented individuals working here is one of our strengths. This sends out a strong signal in these times of increasing restrictions on scientific freedom and international collaboration.” The British university service provider QS Quacquarelli Symonds compiles its university quality rankings through surveys of academics and employers. It also assesses the number of citations of published research, the faculty-student ratio and the success of graduates. Further criteria include the share of international students and staff, international research collaborations and sustainability aspects. The QS Ranking is one of the most widely recognized university rankings alongside the THE World University Ranking and the Academic Ranking of World Universities (“Shanghai Ranking”), in which TUM holds the 26th and 47th places, respectively. THE also ranks TUM as the best university in the European Union.
The renowned British magazine Times Higher Education (THE) examines the global relevance of universities in various categories for the "University Impact Ranking". In the area of industry, innovation, and infrastructure, THE records the number of research publications in significant fields for sustainable innovations, such as energy, Industry 4.0, and smart cities. The ranking also considers how often research papers are cited in patents, how many start-ups are spun off, and how much third-party research funding universities receive from the industry. TUM again achieved the highest possible score and ranked first for the fourth time – this time alongside eleven other universities.
Hosted under Singapore’s National Research Foundation (NRF) Campus for Research Excellence And Technological Enterprise (CREATE), TUMCREATE has contributed to advancing scientific solutions and a legacy of impact. TUMCREATE has been driving research across diverse domains such as electromobility, sustainable food solutions and processing technology, energy systems, and health tech with other leading Singaporean and global universities and research institutes. TUMCREATE’s current flagship programme, Proteins4Singapore, addresses the critical need to ensure a sustainable, nutritious, and secure food supply in rapidly growing urban environments and supports Singapore’s ‘30 by 30’ food security goal of producing 30% of its nutritional needs domestically. The collaborative environment at TUMCREATE has enabled deep academic and research exchanges leading to positive results. One successful milestone was EVA, the world's first electric taxi for the tropics, developed in 2015 in collaboration with Nanyang Technological University. TUMCREATE’s simulation technologies City Mobility Simulator (CityMoS) and Multi Energy System Modelling & Optimisation (MESMO) have been used in various government and industry projects to support the electrification of Singapore’s transport systems, infrastructure planning, and traffic flow optimisation. Based on a digital twin of Singapore, CityMoS’s utilisation to simulate traffic and mobility systems in real time has extended beyond Singapore through its commercial spin-off, intobyte. TUM President Prof. Thomas F. Hofmann says: “TUMCREATE, as a vital part of our activities in Singapore, exemplifies the spirit of scientific excellence, the passion for impact, and the added value of international cooperation that defines our university’s global mission. It brings together talents from different disciplines and continents, converges German engineering competences and Asian ingenuity, and connects TUM’s entrepreneurial spirit with Singapore’s dynamic innovation systems. I am confident that our teaching and research activities in Singapore will help to to shape a smarter, more sustainable future - together.” Bavaria’s Science Minister Markus Blume says: Bavaria's Minister of Science Markus Blume says: "Happy birthday! We are celebrating the 15th anniversary of an international success story. The cooperation between our Bavarian innovation ambassador, TUM, and the who's who of innovation makers from Singapore has created a very special spirit. TUMCREATE is a strong platform for research cooperation between the innovation regions of Bavaria and Singapore – a bridge of excellence between the continents. For us, it is clear that innovation comes from cooperation. TUM has long been a pioneer in the field of internationalization of our universities. As Bavaria, we are now further expanding our cooperation with the Asia-Pacific region through our new BayAP university and innovation center. This will also give TUM's strong commitment even more momentum." Professor Subodh Mhaisalkar, NRF Executive Director says: “Over the past decade and a half, TUMCREATE has built robust partnerships with local institutions and industry, developing innovative solutions across various domains including sustainability, urban mobility, food sciences and nutrition. While bridging the gap between cutting-edge research and practical applications, the centre has provided solutions for topics related to deployment of electric vehicles, cargo management, and resource circularity.”
For over 22 years, TUM has maintained a strong presence in Singapore. With its recent relocation, TUM Asia is now strategically positioned at two locations, on the campus of NTU as well as on the new campus of the Singapore Institute of Technology (SIT). Beyond its academic offerings, TUM Asia also encompasses TUMCREATE, a multidisciplinary research platform located at the Singapore Campus for Research Excellence and Technological Enterprise. Together with partner universities, public institutions, and industry partners, TUMCREATE is driving cutting-edge research in areas such as protein science, sustainability, medical diagnostics, mobility, and energy. The mission of BayAP is to promote international academic collaboration by supporting Bavarian universities and researchers in expanding their global partnerships. As a central hub, it aims to foster synergies between Bavarian and Singaporean institutions of higher learning, as well as their respective start-up and innovation ecosystems - particularly in the fields of deep tech, innovation, and entrepreneurship. TUM President Prof. Thomas F. Hofmann emphasized: "The expansion of TUM into Singapore has marked a significant milestone in the internationalization strategy of our university. It has become both a role model and one of our key success factors. In today’s interconnected world, international cooperation is vital to addressing the grand challenges humanity is facing. Therefore, we further strengthend our engagement in Singapore by entering into a flagship partnership with NTU last year." Bavaria’s Science Minister Markus Blume stated: “Bavaria and Singapore share a strong culture of innovation, a high quality of life, and economic success. We are deepening our collaboration – and both sides will benefit. For us, Singapore is the gateway to the Asia-Pacific innovation region. With our university and innovation center BayAP, we are positioning ourselves as a European high-tech location and a premium research partner. The BayAP is the first official presence of a German federal state in research in Singapore. This marks a strategic milestone in the internationalization of our universities. And we are once again breaking new ground – just as we did over 20 years ago: in 2002, we established TUM Asia, the first international campus of any German university. Today, with BayAP, we are creating a point of contact for all Bavarian universities – a center for networking, matchmaking, and support programs. At the same time, this branch is an invitation to high potentials from the Asia-Pacific region to come to Bavaria.” Dr. Markus Wächter, Managing Director of TUM Asia, added: "TUM Asia’s relocation to NTU underscores our long-term commitment to growth and deeper academic integration within Singapore’s dynamic educational landscape. This new location not only reinforces the flagship partnership between TUM and NTU, but also houses the regional support office for the Bavarian University and Innovation Center Asia-Pacific. Through this initiative, we aim to catalyze cross-border research collaborations and foster academic mobility between Singapore and Bavaria." Since its founding in 2002, TUM Asia has graduated over 3,000 students from more than 45 countries, offering doctoral, master’s, and bachelor’s degree programs, alongside an extensive portfolio of lifelong learning opportunities. Students enrolled in TUM Asia’s degree programs receive diplomas directly from TUM, while participants in joint programs earn degrees conferred jointly by TUM and its partner universities in Singapore.
To date, researchers at TUM have secured a total of 240 91ɫ Grants, including 46 Advanced Grants. These prestigious awards target established researchers who have achieved significant scientific success over the past ten years. Each grant provides up to €2.5 million in funding.
For the first time, the 91ɫ (TUM) and the Robotics Institute Germany (RIG) are appearing side by side at Automatica. Under the high-tech platform munich_i, MIRMI, TUM's integrated institute for robotics and AI, provides a multifaceted insight into practical applications. The approximately 25 onsite demos include a mobile environmental laboratory equipped with a drone, submarine and small terrestrial robot, exosuits that support the upper body or legs, and startups such as SmartAIs, which uses AI to help blind people with orientation. Special thematic focuses here are on two crucial strategic topics of MIRMI: geriatronics and the question of how technology can support people in care and old age, and how KI.Fabrik deals with AI and robotics in the production environment. In addition, several start-ups are supported by the MIRMI incubator robo.innovate. RIG STAGE: Stage program featuring many TUM researchers The stage program will kick off on the first three days with short presentations of selected demos. The RIG STAGE, under the auspices of RIG, will focus on environment and mobility, health, work and young talent. MIRMI will be represented by many speakers and panel members, including MIRMI Director and RIG Coordinator Prof. Angela Schoellig and MIRMI Executive Director Prof. Lorenzo Masia. Ethics professor Alena Buyx and professor of science and technology studies Ruth Müller will discuss responsibility in automation, while robo.innovate manager Nicole Ebner and MIRMI board member Prof. Eckehard Steinbach will bring start-ups to the stage. In addition, researchers from RIG partner universities will present some of RIG's recently approved research clusters, among other topics. Robotics and AI at the munich_i Hightech Summit: top researchers meet industry The international congress ‘munich_i Hightech Summit’, scheduled for the opening day of Automatica on June 24, 2025, will focus on ‘Visions of future robotics and AI.’ In four different sessions, internationally renowned researchers will discuss "Autonomy and interaction in robotics," "Networking of cooperative robots," "Generative AI in robotics and big data" and "Future medical robotics". The event is remarkable for bringing together the worlds of research and industry. While the Alan Turing Institute conducts research on machine learning for future generations of robots, TU Dresden on AI and robotics in the operating theater, and the University of Pisa on human-robot integration, companies are already putting modern AI and robotics into practice. Honda, Google, Meta, and Continental, among others, will be on hand to provide insights. Robothon at munich_i: 10,000 euros in prize money An almost traditional highlight of Automatica is back for the fourth time this year, with the Robothon competition again pitting international research teams vying to demonstrate the superior agility and responsiveness of their robot platforms. The tasks will involve electronic waste disposal. After solving the standard task, the teams will show off the skills of their own devices in the Bring-Your-Own-Device Challenge. A jury of industry experts and top researchers will keep score for the eight competing teams from Germany, Ireland, India, and the United Arab Emirates. At the award ceremony on June 27, the winning teams share the total prize money of 10,000 euros. automatica: ‘The entire spectrum of robotics and AI’ "At automatica, we showcase the entire spectrum of robotics and AI – from practical solutions in the demo area to a robotics competition, various presentations and panel discussions, and a high-profile international conference. It's a great mix," says Prof. Lorenzo Masia, Executive Director of MIRMI.
When standard treatments for diseases like cancer fail, custom-tailored cell therapies are increasingly becoming a viable option. A prominent example is CAR T-cell therapy. In this approach, immune cells are taken from the patient and genetically engineered in the lab to carry a receptor that recognizes structures specific to the surface of cancer cells. These modified immune cells then multiply in the body and initiate an immune response against the tumor. Physicians could greatly benefit from knowing exactly how these modified immune cells behave in the body: Do they migrate to where they are needed? Do they replicate sufficiently? Do they behave unpredictably and, in the worst-case scenario, attack healthy tissue? Currently, there are no clinically applicable methods to answer these critical questions.
Whether in mice, cats, or humans: Even before vertebrates open their eyes, a built-in training program begins in the retina — entirely independent of external stimuli. Spontaneous activity patterns spread in wave-like motions across the eye’s neural tissue. This neural activity, known as “retinal waves”, coordinates the early wiring between the retina and the brain’s visual system. In a way, the eye starts practicing vision before encountering the real world. Researchers at TUM have now shown that artificial neural networks — which mimic the function of the brain — can also benefit from this kind of pre-training. “Artificial neural networks are typically trained using data that closely resembles the task they’re intended to perform. When viewed in analogy to how the visual system develops in living organisms, their learning process begins only when the eyes open. We took inspiration from nature and incorporated a pre-training stage, analogous to that in the biological visual system, into the training of neural networks,” says Julijana Gjorgjieva, Professor of Computational Neuroscience at TUM.
Around two thirds of all cancer patients look for information about their illness online. They submit questions to chatbots, scroll through forums, click their way through portals, where the information they find is often obsolete, incomplete or false. Medical specialists also make frequent use of digital resources when searching for treatments or information on correct medication dosages and face the same problems. That is the starting point for the AIdvice Assistant, an AI-supported search tool that will be developed and tested by researchers at TUM and the TUM University Hospital over the coming years. They will be supported by 1.5 million dollars in funding from the Google.org Accelerator: Generative AI. With its project, TUM was chosen as one of 20 non-profit organizations worldwide.
She wishes to remain anonymous. Others who are currently studying or working at Harvard University no longer respond to inquiries. This is understandable, as attracting negative attention from the U.S. government could result in the loss of one's visa. The young woman talking to us is studying in a master's program at the TUM School of Computation, Information and Technology. Until a few days ago, she was a visiting researcher as part of a study program at Harvard Business School. She came to the USA at the beginning of the year with a "J1 Student Internship" visa, i.e. a residence permit for a student internship. Harvard had already recommended that she entered the country before Trump's inauguration on January 20. "It was anticipated early on that there could be difficulties." However, when entering the country, it also depends on which border officials you meet. The TUM student left and re-entered the country once over Easter. "The border officer was very friendly and congratulated me on Harvard." But she had also heard of completely different experiences. She has since left the country, a plan she had already made earlier.
The research, published in the academic journal Nature, represents an essential step in quantum computing and demonstrates its potential by directly simulating fundamental interactions with Google's quantum processor. In the future, researchers could use this approach to gain deeper insights into particle physics, quantum materials, and even the nature of space and time itself. The aim is to understand how nature works at its most fundamental level, described by so-called gauge theories.
Which universities are the best at training their students to work with digital technologies? Which graduates contribute to the innovative strength of the digital economy? Where did the digital leaders of large companies and start-ups study? To find out, the consulting firm Emerging identified the university degrees of 150,000 digital professionals working for the world's most innovative companies. In addition, 2,000 managers, specialists and start-up founders in digital sectors were asked about the best degree programs and graduates. At 7th place, TUM is once again among the top 10 in the Digital Leaders in Higher Education rankings, the only university in the European Union to do so. In the fields of Computer Science and Digital Entrepreneurship, TUM is ranked 4th, thus belonging to the top quartet alongside the University of Cambridge, Harvard University and the University of Oxford and MIT, respectively. It placed 9th in the Digital Transformation Management field of study. Other rankings also demonstrate that TUM optimally prepares its students for the professional world. In the Global University Employability Ranking, for which around 13,000 managers in more than 30 countries are surveyed, TUM holds the 13th position. In the CHE University Rankings, students regularly give very good ratings for the study conditions and the courses on offer. The QS Best Student Cities Ranking ranks Munich 4th as a location for studying abroad.
The Fusix virus wreaks havoc in tumor cells – with the goal of fighting cancer and saving lives. It does so by causing an infected tumor cell to produce large amounts of a protein that anchors itself to the cell’s surface. This sends a signal to neighboring cells to fuse with the infected one. They obey immediately: first one, then the next, and so on – until the entire structure literally bursts. The released cell contents trigger the immune system. Alerted immune cells clear the debris, attack intact cancer cells that had previously evaded immune detection, and help limit the virus’s further spread. This approach could one day help treat tumors that don’t respond to conventional therapies. At the Clinic and Polyclinic for Internal Medicine II at the TUM University Hospital, Jennifer Altomonte is developing virus-mediated immunotherapies. She laid the scientific foundation for Fusix back in 2016. At the time, Altomonte was exploring ways to employ viruses to fight cancer.
In a laboratory at Nanyang Technological University (NTU) in Singapore, flickering monitors show a succession of satellite images, soil data, and chemical analyses from the university’s nearby experimental field. Anna Lena Salfer is part of a research team investigating the potential of enhanced rock weathering as a method of binding carbon in land used for agricultural purposes. Alongside geoscientific modeling, the team’s analyses primarily draw on data from international emissions trading registries, which help to improve their understanding of the criteria used in standardizing and certifying carbon reduction technologies. Their research assists in supporting credible emissions trading schemes in south-east Asia, representing a key step towards establishing sustainable climate protection strategies in the region.
Decker said of his new role: "What sets the Deutsches Museum apart is that it doesn't just exhibit new scientific discoveries and new technologies, but also provides a forum for discussing their potential consequences for society – both positive and negative. Museums have been shown to enjoy high trust among the public – and I would like to take advantage of this. And the more visitors, the more children come, the better." He sees it as a great honor and responsibility to lead the museum. The Deutsches Museum is considered the world's largest museum of science and technology. Decker was appointed professor to the Oskar von Miller Chair of Science Communication at TUM in the spring, a position previously held by Heckl. Before that, Decker was a professor of technology assessment at the Karlsruhe Institute of Technology (KIT). The 59-year-old studied physics in Heidelberg and also earned his doctorate there. He completed his habilitation at the University of Freiburg. Most recently, he was head of the Department of Computer Science, Economics, and Society at KIT.
Green hydrogen is considered an important component for climate-friendly industrial production, for example in the steel industry. Hydrogen is regarded as ‘green’ when the electrolysis used to produce it is powered by renewable energy sources. Because Europe is unlikely to be capable of meeting its own needs, the focus has increasingly shifted to Africa in recent years. Governments and the private sector have high hopes that production sites for export could be developed in African coastal countries with favorable conditions for solar and wind power. The first projects are currently being planned, although most plants are still in the concept development stages. When analyzing these projects, researchers at TUM, the University of Oxford and ETH Zurich observed that the cost estimates were highly imprecise in many cases. “Most of the conventional models for green hydrogen plants typically use uniform financing costs. However, the investment environment is different in every country and is subject to especially high risks in many African countries,” says Florian Egli, who holds the Professorship for Public Policy for the Green Transition at TUM. Consequently, the research team developed a new method for calculating the financing costs of green hydrogen production facilities, in other words the costs to the plant operators for raising capital for their investments. This takes into account the specific conditions for hydrogen production in 31 African countries such as transportation and storage options and the degree of legal certainty and political stability. The model assumes that the production plants will be operational by 2030 and that the hydrogen will be converted into ammonia and shipped to Rotterdam.
Emmanuel Adjei is an enthusiastic cyclist and has already completed several ambitious tours. But what he plans with “Bike2MyRoots” is a whole new dimension even for him: he will cover around 10,000 kilometers, crossing mountains, seas, and deserts. “It’s a bit crazy – but that’s the point: I want to show the children in Ghana that you can achieve anything – even if it seems a bit crazy at first!”
The DFG's Collaborative Research Centers are among the most important research funding programs in Germany. They enable ambitious, interdisciplinary and long-term research projects. Collaborative Research Centers whose partners cooperate on a supra-regional level are called Transregios. TUM was successful twice in the current selection round: SFB/Transregio “Data-driven agile planning for responsible mobility” How can the forecasting and management of traffic flows be improved? And how can the various interests of traffic participants be taken into account in a more balanced way than before? The AgiMo Collaborative Research Center aims to develop new methods for agile mobility planning using a comprehensive approach based on data and computer models. New criteria for responsible mobility based on the so-called 4F principles - Function, Form, Fairness and Forever - are to be defined and applied. On this basis, the researchers want to develop a digital twin in order to make data and models available open source. They also want to investigate how all relevant stakeholders can participate in the design of evidence-based future scenarios. To this end, the technical and social sciences are working closely together at AgiMo. Applicant universities: TU Dresden and TUM Responsible at TUM: co-spokesperson Prof. Dr. Klaus Bogenberger, Chair of Traffic Engineering and Control, and Prof. Dr. Allister Loder, Professorship of Mobility Policy Spokesperson: Prof. Dr. Regine Gerike (TU Dresden) Partner institutions: TU Berlin, TU Braunschweig and German Aerospace Centert (DLR) SFB/Transregio “Simulation-based learning in higher education: Advancing research on process diagnostics and personalized interventions (SHARP)” In many professions, such as medicine and school teaching, increasingly complex analytical and communication skills are expected. Students could be better prepared for these requirements with simulations training them in practical situations with virtual patients or simulated pupils. The SHARP Collaborative Research Center will investigate how such simulations can be designed and applied. The researchers want to use artificial intelligence to adapt simulations to the respective level of competence and different needs. They also want to investigate what skills university lecturers need to be able to implement personalized, simulation-based learning effectively in degree courses. SHARP is the first Collaborative Research Center in educational research and brings together the disciplines of psychology, educational science, computer science, mathematics, medicine, biology, chemistry and physics. Applicant universities: LMU and TUM Responsible at TUM: co-spokesperson Prof. Dr. Tina Seidel, Friedl Schöller Endowed Chair for Educational Psychology Spokesperson: Prof. Dr. Frank Fischer (LMU) Partner institutions: University of Augsburg, Leibniz Supercomputing Centre The German Research Foundation has established a total of 13 new Collaborative Research Centers. From October 2025, they will initially be funded for three years and nine months with a total of around 177 million euros.
"Increasing innovative power to strengthen Germany's competitiveness is one of the key tasks for the future. As a link between scientific invention and economic innovation, acatech has a key role to play here. As acatech President, I would like to work to further strengthen this important role of acatech in the innovation system and to substantially support Germany's competitiveness by actively helping to shape technology-driven innovation," says Claudia Eckert. "We cannot solve the great challenges of our time with the same approach that we used when we created them," emphasises the acatech President-designate, freely paraphrasing Albert Einstein. "The wide-ranging scientific excellence of acatech's members and partners forms the indispensable foundation of our work. On this basis, we develop new approaches, impulses and concrete recommendations for policymakers based on facts and evidence. Building on this and in close dialogue with politics, business and society, we identify future-oriented options for action and provide guidance on how Germany can strengthen its future viability." "In Claudia Eckert, an excellent technology scientist and sought-after IT security researcher, is taking over the role of acatech President," says outgoing President Jan Wörner. "Claudia Eckert's research is of outstanding importance for the security, resilience and innovative capacity of our country. As acatech President, she will bring enormous benefits to the Academy and our innovation hub with her profound experience and networking," emphasises Co-President Thomas Weber. Claudia Eckert is Professor for IT Security at TUM and executive director of the Fraunhofer Institute for Applied and Integrated Security AISEC. She researches new methods and technologies to increase the security and trustworthiness of digital, networked systems. Claudia Eckert is a long-standing member of the Bavarian Academy of Sciences and Humanities and has been an acatech member since 2010; she became a member of the acatech Executive Board in 2014. In 2023, TUM honoured her with the Heinz Maier-Leibnitz Medal for her outstanding contributions in the field of IT security.
Unlike men, who carry one X and one Y chromosome, women have two X chromosomes in each cell. However, one of the two X chromosomes is effectively silenced. It folds into a compact structure known as the Barr body and can no longer be read. Without this mechanism, the genes on the X chromosome would be read twice as often in women as in men. Scientists have known for some time that some genes can escape inactivation in the Barr body, resulting in higher gene activity in women. These genes are suspected to influence disease. “We have now shown for the first time that with increasing age, more and more genes escape the inactivation of the Barr body,” says Dr. Daniel Andergassen, group leader at the Institute of Pharmacology and Toxicology at TUM. The study was published in the journal Nature Aging.
The need to design technologies responsibly is something that we’re hearing more about all the time. Why do we need a major research cluster dedicated to this topic? That’s true. It is good to see that this topic is much more prominent today than five years ago. But there is still a sense that we’re just getting started. We still lack good answers to many questions. The ethics boards set up by big tech companies frequently fail. Start-ups scale up more rapidly all the time. And we keep being taken by surprise by apparently unexpected dynamics such as the “ChatGPT moment”. With TransforM, we want to investigate these transformative innovation dynamics and learn to control them better. But we also want to flip the logic of innovation on its head to some extent. Less of the attitude: “Here’s an amazing new technology – what can be done with it and how do we make it profitable and more or less socially acceptable?” Instead we want to ask: “What kind of innovation do we actually need and want? What are the societal problems that we want to solve? And what role does technology play, for example with regard to mobility justice, health care, AI or regional competitiveness?” We want to join forces with all relevant disciplines to study how to shape processes of this kind. But haven’t these disciplines already been working together for quite some time? At TUM and some other universities, we have seen enormous progress over the past 10 years. But surprisingly, Germany as a whole still lags behind other countries in breaking down the walls between the social sciences and natural science and engineering disciplines in order to release new potential for exciting research. On the one hand, the transformative power of technology is far from being at the center of social science research, although there is probably no societal issue that is not deeply affected by technology. In Europe there is no comparable initiative in which the social sciences address the topic of technology in such a concentrated form as TransforM. I myself come from the field of science and technology studies, STS. My co-spokespersons Hanna Hottenrott and Holger Patzelt specialize in the economics of innovation and entrepreneurship research, respectively. In addition, we have participants from the fields of governance, sociology, management, economics, international relations, consumer science, anthropology, history, operations research and other areas – from TUM as well as LMU, Max Planck, ifo, ZEW and the Munich School of Politics and Public Policy. On the other hand, social scientists are often brought on board technology projects as a mere formality, where they are expected to make some sort of contribution under the heading of societal acceptance. That’s a bit like asking an AI professor to install a software update on my PC. The separation is not as sharp as it used to be. But it’s still there. So how should research be conducted? The world of social science shouldn’t just wait for years to see what comes of a new technological development. We have to face questions at an early stage and in real time, even if these questions are highly speculative. At present, for example, we have to look into quantum computing although nobody knows at this stage whether, how and for whom this technology will specifically function. Consequently, social scientists should be close to the laboratory right from the start of research projects. To achieve that, we want to develop a dialog competency in TransforM and also try out new forms of collaboration. For example, we want to create a new integration platform, called SCOPE, through which we will address socio-technological issues and research projects with partners from the world of technology. Which topics will these projects deal with? One example might be the question of how autonomous driving can work across national borders, which are still cultural and regulatory boundaries. With our platform, we can address this question not only from a social sciences perspective, in other words with researchers who study political culture, international standards, corporate responsibility or the principles of open data use. We can also explore these issues with those who develop autonomous systems and infrastructure concepts, for example my TUM colleagues Markus Lienkamp, Klaus Bogenberger, Johannes Betz and Alois Knoll. We intend to establish an overall pool of around 20 experienced experts covering various topics who will be available to advise us in real time. And we have already done pioneering work in that regard at TUM, for example in the area of embedded ethics and social science with my colleagues Ruth Müller and Alena Buyx. You have made several mentions of real time. What do you mean by that? We want to be in a position to respond to shocks in our socio-technological world from a social sciences perspective while they can still be felt. An example would be the covid pandemic. Every researcher in the world was affected by it and many responded spontaneously with their research agenda, although these were often very much ad-hoc and unstructured reactions. Where would we have been if we’d had a mechanism at the beginning of the pandemic, in which an interdisciplinary group of 10 social scientists had dropped everything and focused their combined expertise on the issue at hand? And if this group had also had an established link to natural sciences, engineering and health sciences experts in order to work on this topic for several months? That is something that we want to try out with an experimental unit called a real-time response team. And covid is just one example. Especially with the rapid development of digital platforms, certain path dependencies could have been avoided through real-time examination of the options. How does TransforM plan to involve the public? In many areas, technological developments are hardly imaginable without citizen involvement – from bridge construction to genetically modified foods. With TransforM, we want to go beyond the kind of one-off participation where – to put it bluntly – the public are quickly asked to give their ok, often much too late. With our Public Technology Lab, we want to work with the Deutsches Museum to set up a permanent, multi-modal infrastructure for participation with which citizens in the Munich region will be involved in various technological developments – and not only with those segments of the population who already attend university events. In that regard, too, TUM has done trailblazing work, for example in an initiative with my colleagues Jörg Niewöhner, Sabina Leonelli, Anne Rademacher and Silke Beck. We can also learn from other major projects such as the MCube future cluster, where, in so-called sandboxes we have tested many new forms of mobility and ways of embedding them in society. What opportunities do you see for a genuine change in thinking when it comes to the shaping of the technological and societal transformation? We are seeing encouraging examples. Advances in neurotechnologies such as brain-computer interfaces have been more cautious and inclusive than with genetic engineering – although such flagship initiatives as the Human Genome Project and Human Brain Project were similarly gigantic in scale. Many social science concerns were taken into account at an earlier stage and, up to a point, a regulatory toolbox and a discussion culture were developed. Of course there is plenty of room for improvement. But we also see that it is much harder today to inject issues of public acceptance, social justice, political legitimacy and sustainability into the current debates than just a few years ago because the discussions now revolve around military security and competition between economic powers. That is unfortunate, because the ability to combine economic and foreign policy strength with a model for a livable, inclusive and socially just society could be a competitive advantage for Europe. With that in mind, TransforM aims to contribute to better innovations and innovation strategies.
ZDF-Morgenmagazin reporter Moritz Neuß visits the Learning Systems and Robotics Lab of Prof. Angela Schoellig and accompanies him on the streets of Maxvorstadt in Munich. Research assistant Sepehr Samavi helped develop the vehicle. Link to the article: https://www.zdf.de/nachrichten/zdf-morgenmagazin/moma-future-roboter-lernt-menschenlauf-100.html
Professor Engelhardt, in recent years, RNA research has gained widespread attention, even outside the scientific community. With the record-breaking development of mRNA vaccines against COVID-19, three Nobel Prizes have been awarded in the past four years. Why is that? Scientists have known about RNA for many decades. We have also long understood that various RNA molecules play key roles in the development of disease. But now, we've reached a point where we can therapeutically target these molecules. Combined with CRISPR technology, this opens up entirely new possibilities. Do we fully understand how RNA works? Definitely not. But we do know a great deal more today. In some areas, we've made significant progress, such as with messenger RNAs, or mRNAs, which carry the blueprint for proteins. In others, such as non-coding RNAs, many questions remain unanswered. But research groups around the world are working on these issues, and we aim to make a key contribution through the NUCLEATE Cluster of Excellence. What do the advances in RNA research mean for medicine? As a pharmacologist, I focus on drugs, and at the moment we’re witnessing a revolution in this field. I expect that within the next ten years, we will see the rise of a third major class of drugs – nucleic acid-based therapeutics. Can you explain that in more detail? The most important class so far has been small-molecule drugs that bind to proteins in the body – everything from aspirin to cancer therapies. Since the 1980s, we’ve also had so-called biologics, including artificially produced antibodies. These also bind to proteins. And nucleic acid-based drugs don’t? Exactly. While they ultimately affect proteins, they do so indirectly by specifically regulating the genes or RNA precursors of proteins. For example, by binding to RNA, they can prevent certain proteins from being made in the first place. Conversely, you can introduce the blueprint for a particular protein into the body, as is done with mRNA vaccines. What’s the advantage of this approach? There are currently fewer than 3,000 approved drugs, and they target only about 600 of the roughly 20,000 proteins in the human body. That means conventional drug classes can’t reach a large number of biological mechanisms. With the ability to inhibit RNAs, in principle, we can influence virtually any protein. What are the biggest challenges for RNA-based drugs right now? The three biggest challenges are “delivery,” “delivery,” and “delivery.” That is: getting the drug safely and precisely to the part of the body where it’s needed is far from trivial – and this is the main hurdle preventing widespread adoption of nucleic acid therapeutics. But even here, we're seeing major progress. For example, we've developed a compound that is selectively taken up by specific immune cells, where it targets a microRNA and can effectively prevent tissue damage in lung inflammation. Being a pharmacologist, would you say that research on nucleic acids is a major part of this field? At the TUM Institute of Pharmacology and Toxicology, it certainly is. But as is often the case, colleagues from a wide variety of disciplines across TUM are making crucial contributions. Take virology, for example: my colleague Ulrike Protzer studies pathogens that are essentially replication machines for nucleic acids. Understanding these mechanisms can help us develop counterstrategies. Cancer researchers like Roland Rad are investigating how nucleic acids behave in tumors and have developed world-leading screening methods. And it goes beyond medicine. What other fields are involved? We also need fundamental research on the structure and function of nucleic acids. For instance, Carina Baer de Oliveira Mann at the TUM School of Natural Sciences uses innovative electron microscopy technologies to study this. Also, without bioinformatics, none of our research would be possible. We need highly specialized tools, which people like Fabian Theis develop. His AI-based tools, for example, can predict how a cell will change over time based on a “snapshot” of the molecules in it. You have been the co-lead of CNATM, an industry-academia consortium focused on nucleic acid therapeutics, for some time now. Many institutions from Munich and Bavaria are involved, and it is the only consortium on this topic in Germany. Is this a particular strength of the region? Absolutely. Many key players in this field are based here. Expertise comes from a wide range of areas, including immunology and the structural chemistry of nucleic acids, with colleagues like Veit Hornung and Thomas Carell at LMU. Another example is RNA research in bacteria, which Cynthia Sharma and Jörg Vogel at the University of Würzburg are working on. This is important because it could potentially lead to the development of new antibiotics based on nucleic acids. Beyond research institutions, the greater Munich area now has the highest concentration of small and medium-sized enterprises in nucleic acid research in Germany. There’s a lot happening in this field right now, and we’re a major part of it. I'm very much looking forward to working with my co-spokespeople Cynthia Sharma and Veit Hornung to bring together all this expertise.
Four existing clusters were able to prove themselves in the international review process. They will be funded for a further seven years with a future-oriented focus on energy conversion, quantum technologies, neurological diseases, and the origin of the universe. In addition, there are three new Clusters of Excellence that were able to convince the international review panels with leading research approaches in the fields of nucleic acid research, biosystem design and societal transformation through technologies. "Our excellent scientists and their strong partners once again underline the leading position of Munich science. This has created the conditions for us to be able to compete for the title of University of Excellence for the fourth time in a row since 2006," says TUM President Prof. Thomas F. Hofmann. "Once again, our team spirit and the trustful cooperation between the two Munich universities with the Max Planck Institutes and the Helmholtz Zentrum München, which is based on trust and tailored to their respective strengths, has proven to be the right strategic approach to excellence research," emphasizes Hofmann. Bavaria's Science Minister Markus Blume says: "Gigantic excellence success for our Munich universities: With seven applications each, including six joint ones, TUM and LMU are successful in the race for the Clusters of Excellence. One thing is clear: Munich is the Mecca of excellence in Germany and sets standards for innovation in Europe. TUM and LMU are the best universities in Germany, as they are proving once again here. Munich is particularly radiant today - and the whole of Bavaria is a big winner: all Bavarian cluster applications were successful. We have doubled the number of clusters to twelve. No other state has gained more. Perseverance pays off! With the High-Tech Agenda Bavaria, we have consistently invested in science and research and thus substantially strengthened Bavaria as a science location - the HTA is a real excellence booster."
As innovation incubators, the TUM Venture Labs promote technology-oriented spin-offs and support founders in transforming scientific findings and ideas into marketable products. The twelve Venture Labs - a joint initiative of the 91ɫ (TUM) and UnternehmerTUM - offer an ecosystem tailored to cutting-edge technologies. As one of the core partners of the TUM Venture Lab Aerospace, which also coordinates defense-related topics across the board, Hensoldt will support start-ups focusing on the accelerated development of security and defense technologies in the future. TUM President Prof. Thomas F. Hofmann emphasizes: "The global security situation has changed fundamentally. New threats, hybrid forms of conflict, and a changed understanding of security policy roles in familiar partnerships require Germany and Europe to take decisive action and strengthen the sovereignty of their own defense capabilities. To protect our population, democracy, and preserve peace, we want to use our technologies to accelerate the modernization of our defense capabilities. The catalysts for this are our TUM Venture Labs, which together with industry partnerships form a unique innovation ecosystem for start-up talent in Europe." As an industry partner, Hensoldt contributes many years of expertise to the TUM Venture Labs and provides founders with practical insights into industrial requirements and processes. Oliver Dörre, CEO of Hensoldt, explains: "Innovation can only succeed together. By working closely with excellent research institutions such as TUM and through direct exchange with founders, we are creating a strong network for technological sovereignty. Together, we want to provide new impetus, promote cooperation, and make targeted investments in future technologies." Hensoldt, headquartered in Taufkirchen near Munich, develops sensor solutions for security and defense-related applications and is one of the leading companies in European defense electronics. Dr. Philipp Gerbert, CEO of TUM Venture Labs, adds: "As the leading European DeepTech Entrepreneurship Hub, TUM Venture Labs and our partners in Munich are central to defense-related innovations in the fields of space travel, autonomous systems of all kinds, software and artificial intelligence, cyber security, but also new communication and sensor technologies, quantum technologies, innovative materials and on-demand manufacturing." Dr. Florian Dötzer, Head of the TUM Venture Lab Aerospace, emphasizes: "With Hensoldt, we have an invaluable partner at our side. In view of current geopolitical developments, we must increasingly sensitize our start-ups to what it means to develop products for security and defense-relevant markets."
Researchers at the 91ɫ (TUM), the Max Planck Institute for Solid State Research in Stuttgart, and the University of Stuttgart, with support from the Cluster of Excellence e-conversion, have developed a highly porous, two-dimensional covalent organic framework (COF) based on naphthalenediimide. This framework not only absorbs sunlight but also stabilizes the resulting photo-induced charges, enabling energy storage for more than 48 hours in aqueous environments. The stored charges are not merely retained but can be actively discharged to power an external load, enabling real energetic use. “This material has dual functionality and acts as both a solar absorber and a long-term charge reservoir,” said Dr. Bibhuti Bhusan Rath, lead author of the study and postdoc in the research team of Prof. Bettina Lotsch (director at the Max Planck Institute for Solid State Research). “Its performance exceeds that of many existing optoionic materials – and it does so without relying on metals or rare elements.” By combining advanced optical, electrochemical, and computational techniques, the researchers discovered that water plays a central role in stabilizing the stored charges. Rather than interacting strongly with external ions, water molecules respond to the charges in the COF backbone in a way that creates an energetic barrier, effectively preventing recombination of the light-generated trapped charges and preserving the energy for later release. The material exhibits a charge storage capacity of 38 mAh/g, outperforming similar frameworks and other light-responsive materials such as carbon nitrides and metal–organic frameworks.